When the Damage Is Done: Selecting Patients for Head and Neck Cancer Chemoprevention Trials.
نویسندگان
چکیده
514 Identification of a Human Airway Epithelial Cell Subpopulation with Altered Biophysical, Molecular, and Metastatic Properties Paul C. Pagano, Linh M. Tran, Nawal Bendris, Sean O'Byrne, Henry T. Tse, Shivani Sharma, Jonathan W. Hoech, Stacy J. Park, Elvira L. Liclican, Zhe Jing, Rui Li, Kostyantyn Krysan, Manash K. Paul, Yari Fontebasso, Jill E. Larsen, Shaina Hakimi, Atsuko Seki, Michael C. Fishbein, James K. Gimzewski, Dino Di Carlo, John D. Minna, Tonya C. Walser, and Steven M. Dubinett See related article, p. 491 525 Circulating RANKL and RANKL/OPG and Breast Cancer Risk by ER and PR Subtype: Results from the EPIC Cohort Danja Sarink, Helena Schock, Theron Johnson, Kim Overvad, Marianne Holm, Anne Tjønneland, Marie-Christine Boutron-Ruault, Mathilde His, Marina Kvaskoff, Heiner Boeing, Pagona Lagiou, Eleni-Maria Papatesta, Antonia Trichopoulou, Domenico Palli, Valeria Pala, Amalia Mattiello, Rosario Tumino, Carlotta Sacerdote, H.B(as). Bueno-de-Mesquita, Carla H. van Gils, Petra H. Peeters, Elisabete Weiderpass, Antonio Agudo, Maria-Jos e S anchez, Maria-Dolores Chirlaque, Eva Ardanaz, Pilar Amiano, Kay Tee Khaw, Ruth Travis, Laure Dossus, Mark Gunter, Sabina Rinaldi, Melissa Merritt, Elio Riboli, Rudolf Kaaks, and Ren ee T. Fortner
منابع مشابه
Chemoprevention strategies in lung carcinogenesis.
Chemoprevention entails using specific agents to suppress carcinogenesis and thereby prevent the development of primary or second primary cancers. Because the concept of chemoprevention in patients with or at risk of lung cancer is new, ongoing clinical trials are based on data from epidemiologic and preclinical research, as well as on results of chemoprevention studies in head and neck cancer....
متن کاملStrong Association of CTLA-4 Variation (CT60A/G) and CTLA-4 Haplotypes with Predisposition of Iranians to Head and Neck Cancer
Background: Variations in Cytotoxic T Lymphocyte Antigen-4 (CTLA-4) affect the expression and function of this protein. Objective: We aimed to investigate the association of +49 A/G (rs231775), +1822 C/T (rs231779) and +6230 A/G (CT60, rs3087243) genetic variations, as well as the merged haplotypes in CTLA-4 gene with susceptibility to, or progression of head and neck cancer. Methods: Eighty pa...
متن کاملPositional changes in parotid glands during head and neck radiation therapy
Introduction: Xerostomia is the most common complication due to radiation–induced damage to salivary glands in head and neck cancer radiotherapy and it reduces quality of life. Parotid glands are main glands which they are account for secretion of stimulated saliva. Studies have demonstrated that mean tolerance parotid’s radiation dose under 26-30 Gy result in an increase in t...
متن کاملChemoprevention of cancer--focusing on clinical trials.
Chemoprevention of cancer is reviewed from the viewpoints of action mechanisms and methodology of clinical trials in order to introduce promising agents discovered by in vitro and/or in vivo studies to applications in humans. The clinical trial procedure essentially follows the phase study which has been employed for chemotherapeutic drugs. Chemoprevention of bladder cancer, prostate cancer, ga...
متن کاملRadiation-induced Hypothyroidism in Head and Neck Malignancy
Background and Objective: Hypothyroidism is a known consequence of the external beam radiotherapy to the neck encompassing the thyroid gland for over 40 years. The aim of this study was to find out the incidence of hypothyroidism in patients with head and neck cancer treated with radiotherapy, when radia...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Cancer prevention research
دوره 10 9 شماره
صفحات -
تاریخ انتشار 2017